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1

Binary encoded small-molecule libraries in drug discovery and optimization

John C. Chabala, John J. Baldwin, Jonathan J. Burbaum, Daniel Chelsky, Lawrence W. Dillard, Ian Henderson, Ge Li, Michael H. J. Ohlmeyer, Troy L. Randle, John C. Reader, Laura Rokosz, Nolan H. Sigal

Journal:

Perspectives in Drug Discovery and Design

Year:

1995

Language:

english

File:

PDF, 778 KB

english, 1995

2

Finite Element Modeling of Optic Nerve Head Biomechanics

Sigal, Ian A., Flanagan, John G., Tertinegg, Inka, Ethier, C. Ross

Journal:

Investigative Ophthalmology & Visual Science

Year:

2004

Language:

english

File:

PDF, 747 KB

english, 2004

3

Posterior (Outward) Migration of the Lamina Cribrosa and Early Cupping in Monkey Experimental Glaucoma

Yang, Hongli, Williams, Galen, Downs, J. Crawford, Sigal, Ian A., Roberts, Michael D., Thompson, Hilary, Burgoyne, Claude F.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 3.87 MB

english, 2011

4

Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral-Domain Optical Coherence Tomography

Francis, Andrew W., Kagemann, Larry, Wollstein, Gadi, Ishikawa, Hiroshi, Folz, Steven, Overby, Darryl R., Sigal, Ian A., Wang, Bo, Schuman, Joel S.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

5

Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure

Jan, Ning-Jiun, Sigal, Ian A.

Journal:

Acta Biomaterialia

Year:

2018

Language:

english

File:

PDF, 2.60 MB

english, 2018

6

Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images

Chen, Chieh-Li, Ishikawa, Hiroshi, Wollstein, Gadi, Bilonick, Richard A., Sigal, Ian A., Kagemann, Larry, Schuman, Joel S.

Journal:

Investigative Opthalmology & Visual Science

Year:

2015

Language:

english

File:

PDF, 1.67 MB

english, 2015

7

A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models

Grytz, Rafael, Krishnan, Kapil, Whitley, Ryan, Libertiaux, Vincent, Sigal, Ian A., Girkin, Christopher A., Downs, J. Crawford

Journal:

Computer Methods in Applied Mechanics and Engineering

Year:

2020

Language:

english

File:

PDF, 5.11 MB

english, 2020

8

Glucocorticoids do not promote prosociality in a wild group-living fish

Culbert, Brett M., Ligocki, Isaac Y., Salena, Matthew G., Wong, Marian Y.L., Bernier, Nicholas J., Hamilton, Ian M., Balshine, Sigal

Journal:

Hormones and Behavior

Year:

2021

File:

PDF, 242 KB

2021

9

Morphing methods to parameterize specimen-specific finite element model geometries

Ian A. Sigal, Hongli Yang, Michael D. Roberts, J. Crawford Downs

Journal:

Journal of Biomechanics

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

10

Walking behaviour and glycemic control in type 2 diabetes: seasonal and gender differences-Study design and methods

Kaberi Dasgupta, Cathy Chan, Deborah Da Costa, Louise Pilote, Mirella De Civita, Nancy Ross, Ian Strachan, Ronald Sigal, Lawrence Joseph

Journal:

Cardiovascular Diabetology

Year:

2007

Language:

english

File:

PDF, 794 KB

english, 2007

11

Daily steps are low year-round and dip lower in fall/winter: findings from a longitudinal diabetes cohort

Kaberi Dasgupta, Lawrence Joseph, Louise Pilote, Ian Strachan, Ron J Sigal, Cathy Chan

Journal:

Cardiovascular Diabetology

Year:

2010

Language:

english

File:

PDF, 537 KB

english, 2010

12

Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry

Ian A. Sigal, John G. Flanagan, Inka Tertinegg, C. Ross Ethier

Journal:

Biomechanics and Modeling in Mechanobiology

Year:

2009

Language:

english

File:

PDF, 778 KB

english, 2009

13

Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties

Ian A. Sigal, John G. Flanagan, Inka Tertinegg, C. Ross Ethier

Journal:

Biomechanics and Modeling in Mechanobiology

Year:

2009

Language:

english

File:

PDF, 728 KB

english, 2009

14

Mesh Morphing and Response Surface Analysis: Quantifying Sensitivity of Vertebral Mechanical Behavior

Ian A. Sigal, Cari M. Whyne

Journal:

Annals of Biomedical Engineering

Year:

2010

Language:

english

File:

PDF, 769 KB

english, 2010

15

Mesh-morphing algorithms for specimen-specific finite element modeling

Ian A. Sigal, Michael R. Hardisty, Cari M. Whyne

Journal:

Journal of Biomechanics

Year:

2008

Language:

english

File:

PDF, 1.09 MB

english, 2008

16

Lamina cribrosa thickening in early glaucoma predicted by a microstructure motivated growth and remodeling approach

Rafael Grytz, Ian A. Sigal, Jeffrey W. Ruberti, Günther Meschke, J. Crawford Downs

Journal:

Mechanics of Materials

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

17

Predicted extension, compression and shearing of optic nerve head tissues

Ian A. Sigal, John G. Flanagan, Inka Tertinegg, C. Ross Ethier

Journal:

Experimental Eye Research

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

18

Biomechanics of the optic nerve head

Ian A. Sigal, C. Ross Ethier

Journal:

Experimental Eye Research

Year:

2009

Language:

english

File:

PDF, 623 KB

english, 2009

19

3D morphometry of the human optic nerve head

Ian A. Sigal, John G. Flanagan, Inka Tertinegg, C. Ross Ethier

Journal:

Experimental Eye Research

Year:

2010

Language:

english

File:

PDF, 1.65 MB

english, 2010

20

Dimensions of the human sclera: Thickness measurement and regional changes with axial length

Richard E. Norman, John G. Flanagan, Sophie M.K. Rausch, Ian A. Sigal, Inka Tertinegg, Armin Eilaghi, Sharon Portnoy, John G. Sled, C. Ross Ethier

Journal:

Experimental Eye Research

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

21

A geometric morphometric assessment of the optic cup in glaucoma

Paul G. Sanfilippo, Andrea Cardini, Ian A. Sigal, Jonathan B. Ruddle, Brian E. Chua, Alex W. Hewitt, David A. Mackey

Journal:

Experimental Eye Research

Year:

2010

Language:

english

File:

PDF, 740 KB

english, 2010

22

Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism

J. Crawford Downs, Michael D. Roberts, Ian A. Sigal

Journal:

Experimental Eye Research

Year:

2011

Language:

english

File:

PDF, 1.64 MB

english, 2011

23

Finite element modeling of the human sclera: Influence on optic nerve head biomechanics and connections with glaucoma

Richard E. Norman, John G. Flanagan, Ian A. Sigal, Sophie M.K. Rausch, Inka Tertinegg, C. Ross Ethier

Journal:

Experimental Eye Research

Year:

2011

Language:

english

File:

PDF, 598 KB

english, 2011

24

3D visualization of aqueous humor outflow structures in-situ in humans

Larry Kagemann, Gadi Wollstein, Hiroshi Ishikawa, Ian A. Sigal, Lindsey S. Folio, Juan Xu, Haiyan Gong, Joel S. Schuman

Journal:

Experimental Eye Research

Year:

2011

Language:

english

File:

PDF, 1.43 MB

english, 2011

25

Visualization of the Conventional Outflow Pathway in the Living Human Eye

Larry Kagemann, Gadi Wollstein, Hiroshi Ishikawa, Zachary Nadler, Ian A. Sigal, Lindsey S. Folio, Joel S. Schuman

Journal:

Year:

2012

Language:

english

File:

PDF, 2.67 MB

english, 2012

26

Arterial reactivity following balloon angioplasty in a rabbit model of femoral atherosclerosis

Paul J. LaVeau, Stephen L. Sigal, Michael D. Ezekowitz, Ian J. Sarembock

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1987

Language:

english

File:

PDF, 77 KB

english, 1987

27

Sex and social status affect territorial defence in a cooperatively breeding cichlid fish,Neolamprologus savoryi

Garvy, Kelly A., Hellmann, Jennifer K., Ligocki, Isaac Y., Reddon, Adam R., Marsh-Rollo, Susan E., Hamilton, Ian M., Balshine, Sigal, O’Connor, Constance M.

Journal:

Year:

2015

Language:

english

File:

PDF, 340 KB

english, 2015

28

Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma

Roberts, Michael D., Sigal, Ian A., Liang, Yi, Burgoyne, Claude F., Downs, J. Crawford

Journal:

Investigative Ophthalmology & Visual Science

Year:

2010

Language:

english

File:

PDF, 1.82 MB

english, 2010

29

Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading

Ho, Leon C., Sigal, Ian A., Jan, Ning-Jiun, Squires, Alexander, Tse, Zion, Wu, Ed X., Kim, Seong-Gi, Schuman, Joel S., Chan, Kevin C.

Journal:

Investigative Opthalmology & Visual Science

Year:

2014

Language:

english

File:

PDF, 1.20 MB

english, 2014

30

nMAT4, a maturase factor required for nad1 pre-mRNA processing and maturation, is essential for holocomplex I biogenesis in Arabidopsis mitochondria

Cohen, Sigal, Zmudjak, Michal, Colas des Francs-Small, Catherine, Malik, Sunita, Shaya, Felix, Keren, Ido, Belausov, Eduard, Many, Yair, Brown, Gregory G., Small, Ian, Ostersetzer-Biran, Oren

Journal:

The Plant Journal

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

31

High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability

Ishikawa, Hiroshi, Chen, Chieh-Li, Wollstein, Gadi, Grimm, Jonathan L., Ling, Yun, Bilonick, Richard A., Sigal, Ian A., Kagemann, Larry, Schuman, Joel S.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2013

Language:

english

File:

PDF, 467 KB

english, 2013

32

A Paradigm for Drug Discovery Employing Encoded Combinatorial Libraries

Jonathan J. Burbaum, Michael H. J. Ohlmeyer, John C. Reader, Ian Henderson, Lawrence W. Dillard, Ge Li, Troy L. Randle, Nolan H. Sigal, Daniel Chelsky and John J. Baldwin

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.23 MB

english, 1995

33

IOP Elevation Reduces Schlemm's Canal Cross-Sectional Area

Kagemann, Larry, Wang, Bo, Wollstein, Gadi, Ishikawa, Hiroshi, Nevins, Jessica E., Nadler, Zach, Sigal, Ian A., Bilonick, Richard A., Schuman, Joel S.

Journal:

Investigative Opthalmology & Visual Science

Year:

2014

Language:

english

File:

PDF, 351 KB

english, 2014

34

A comparative study of an innate immune response in Lamprologine cichlid fishes

O’Connor, Constance M., Reddon, Adam R., Marsh-Rollo, Susan E., Hellmann, Jennifer K., Ligocki, Isaac Y., Hamilton, Ian M., Balshine, Sigal

Journal:

Naturwissenschaften (The Science of Nature)

Year:

2014

Language:

english

File:

PDF, 405 KB

english, 2014

35

Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Optic Nerve Head and Peripapillary Retina in Experimental Glaucoma

Strouthidis, Nicholas G., Fortune, Brad, Yang, Hongli, Sigal, Ian A., Burgoyne, Claude F.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 6.07 MB

english, 2011

36

IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: An Analysis of Factor Interactions Using Parameterized Eye-Specific Models

Sigal, Ian A., Yang, Hongli, Roberts, Michael D., Burgoyne, Claude F., Downs, J. Crawford

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 3.95 MB

english, 2011

37

An Applet to Estimate the IOP-Induced Stress and Strain within the Optic Nerve Head

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 2.84 MB

english, 2011

38

IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related?

Sigal, Ian A., Yang, Hongli, Roberts, Michael D., Grimm, Jonathan L., Burgoyne, Claude F., Demirel, Shaban, Downs, J. Crawford

Journal:

Investigative Ophthalmology & Visual Science

Year:

2011

Language:

english

File:

PDF, 2.23 MB

english, 2011

39

Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices

Chen, Chieh-Li, Ishikawa, Hiroshi, Wollstein, Gadi, Ling, Yun, Bilonick, Richard A., Kagemann, Larry, Sigal, Ian A., Schuman, Joel S.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2013

Language:

english

File:

PDF, 952 KB

english, 2013

40

Correlation between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes

Roberts, Michael D., Liang, Yi, Sigal, Ian A., Grimm, Jonathan, Reynaud, Juan, Bellezza, Anthony, Burgoyne, Claude F., Downs, J. Crawford

Journal:

Investigative Ophthalmology & Visual Science

Year:

2010

Language:

english

File:

PDF, 2.22 MB

english, 2010

41

Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects

Girard, Michaël J. A., Dupps, William J., Baskaran, Mani, Scarcelli, Giuliano, Yun, Seok H., Quigley, Harry A., Sigal, Ian A., Strouthidis, Nicholas G.

Journal:

Current Eye Research

Year:

2015

Language:

english

File:

PDF, 2.04 MB

english, 2015

42

Group response to social perturbation: impacts of isotocin and the social landscape

Hellmann, Jennifer K., Reddon, Adam R., Ligocki, Isaac Y., O'Connor, Constance M., Garvy, Kelly A., Marsh-Rollo, Susan E., Hamilton, Ian M., Balshine, Sigal

Journal:

Animal Behaviour

Year:

2015

Language:

english

File:

PDF, 421 KB

english, 2015

43

Reproductive sharing in relation to group and colony-level attributes in a cooperative breeding fish

Hellmann, Jennifer K., Ligocki, Isaac Y., O'Connor, Constance M., Reddon, Adam R., Garvy, Kelly A., Marsh-Rollo, Susan E., Gibbs, H. Lisle, Balshine, Sigal, Hamilton, Ian M.

Journal:

Proceedings Biological Sciences

Year:

2015

Language:

english

File:

PDF, 429 KB

english, 2015

44

Motivation but not body size influences territorial contest dynamics in a wild cichlid fish

O'Connor, Constance M., Reddon, Adam R., Ligocki, Isaac Y., Hellmann, Jennifer K., Garvy, Kelly A., Marsh-Rollo, Susan E., Hamilton, Ian M., Balshine, Sigal

Journal:

Animal Behaviour

Year:

2015

Language:

english

File:

PDF, 510 KB

english, 2015

45

An Open-Label Extension Study to Evaluate Safety and Efficacy of Pazopanib in Patients with Advanced Renal Cell Carcinoma

Sternberg, Cora N., Davis, Ian D., Deen, Keith C., Sigal, Entisar, Hawkins, Robert E.

Journal:

Year:

2014

Language:

english

File:

PDF, 499 KB

english, 2014

46

Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography

Nadler, Zach, Wang, Bo, Wollstein, Gadi, Nevins, Jessica E., Ishikawa, Hiroshi, Bilonick, Richard, Kagemann, Larry, Sigal, Ian A., Ferguson, R. Daniel, Patel, Ankit, Hammer, Daniel X., Schuman, Joel S

Journal:

Biomedical Optics Express

Year:

2014

Language:

english

File:

PDF, 2.17 MB

english, 2014

47

Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

Nadler, Zach, Wang, Bo, Wollstein, Gadi, Nevins, Jessica E., Ishikawa, Hiroshi, Kagemann, Larry, Sigal, Ian A., Ferguson, R. Daniel, Hammer, Daniel X., Grulkowski, Ireneusz, Liu, Jonathan J., Kraus, M

Journal:

Biomedical Optics Express

Year:

2013

Language:

english

File:

PDF, 4.89 MB

english, 2013

48

Social status influences responses to unfamiliar conspecifics in a cooperatively breeding fish

Balshine, Sigal, Hamilton, Ian M., Ligocki, Isaac Y., Reddon, Adam R., Hellmann, Jennifer K., Marsh-Rollo, Susan, O’Connor, Constance M.

Journal:

Year:

2015

Language:

english

File:

PDF, 310 KB

english, 2015

49

[ASME ASME 2009 Summer Bioengineering Conference - Lake Tahoe, California, USA (Wednesday 17 June 2009)] ASME 2009 Summer Bioengineering Conference, Parts A and B - Biomechanics of the Posterior Pole During the Remodeling Progression From Normal to Early Experimental Glaucoma

Sigal, Ian A., Yang, Hongli, Roberts, Michael D., Burgoyne, Claude F., Downs, J. Crawford

Year:

2009

Language:

english

File:

PDF, 813 KB

english, 2009

50

Polarization microscopy for characterizing fiber orientation of ocular tissues

Jan, Ning-Jiun, Grimm, Jonathan L., Tran, Huong, Lathrop, Kira L., Wollstein, Gadi, Bilonick, Richard A., Ishikawa, Hiroshi, Kagemann, Larry, Schuman, Joel S., Sigal, Ian A.

Journal:

Biomedical Optics Express

Year:

2015

Language:

english

File:

PDF, 3.30 MB

english, 2015

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